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FIFTH PUBLICATION, JANUARY 2017. THE Bioscientist. vol.5

The Bioscientist: Vol. 5(1): 57-65, January 2017
Available online at http://www.bioscientistjournal.com
Ihekwereme et al., 2017 Page 57


*¹Chibueze Peter Ihekwereme, ²Felix Ahamefule Onyegbule; ² Ndidi Veronica Okeke and
³Caroline Ogochukwu Obi,

¹Department of Pharmacology & Toxicology,
²Department of Pharmaceutical and Medicinal Chemistry,
³Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical
Sciences, Nnamdi Azikiwe University, Awka, Nigeria.

*Corresponding Author’s Email: cp.ihekwereme@unizik.edu.ng


Even though Citrus plants have antimalarial properties, there is no report of such about peels of
C. maxima. This study explored fractions of peels of C. maxima for the presence of antimalarial
activity using murine models. The crude extract was tested at 3 dose levels (125, 250, 500
mg/kg/b.w./day) and fractions at 2 dose levels (250 and 500 mg/kg/b.w./day). All treatments
lasted 7 consecutive days. In the experimental design and layout, blood samples were collected
from tails of animals on day 4 and day 7. Over 89% of the parasite was cleared by 125 mg/kg
dose on day 7. The highest clearance at day 4 and day 7 were at 500 mg/kg aqueous fraction
(84.85%) and 500 mg/kg ethyl acetate fraction (97.96%), respectively. Only the aqueous
fractions (250 and 500 mg/kg) had clearances > 80% on day 4. Other fractions having clearances
> 50% were 500 mg/kg n-butanol (61.90%) and 500 mg/kg n-hexane (59.57%). Results of day 7
show the presence of antimalarial principles in all the fractions. This study demonstrated that the
fruit peels of C. maxima possess antimalarial activity. More studies are needed to identify the
mechanisms of action and active compounds involved.

Keywords: Citrus maxima, antimalarial activity, parasite clearance, Plasmodium berghei

© 2013. Journal of Faculty of Biosciences, Nnamdi Azikiwe University,

P. M. B. 5025 Awka, Nigeria.

email: thebioscientist@unizik.edu.ng

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