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PUBLICATION, JANUARY, 2014. The Bioscientist. Vol. 2

The Bioscientist Vol. 2 (1): 37-40, January 2014.
Available online at http://www.bioscientistjournal.com
Okafor et al.,2014. Page 37

The Effect of The Ethanolic Extract of The Leaf of Chromolaena odorata on
The Liver of Wistar Albino Rats..

Okafor,C.S; Amuluche1, C.S; Ezinwa, L.L; Nnabuenyi, O.H and Okafor, N.C.
1Dept. of Applied Biochemistry, Nnamdi Azikiwe University, Awka, Nigeria.
2 Dept. of Science Lab.Technology, Federal Polytechnic, Oko.
3 Dept. of Medical Lab.Science, Nnamdi Azikiwe University, Awka, Nigeria.

*Corresponding author email: chikeoka@gmail.com.

ABSTRACT (Download PDF )

The study investigated the hepatotoxic effect of the ethanolic extract of Chromolaena
odorata leaf on groups of male wistar albino rats. The rats were divided into 3 groups of 5
rats each .Group A and B which were the treated groups received 10mg/kg and 20mg/kg
body weight of the extract .Group C (control) was given 5% solution of tween 80 only. The
administration of the extract was done orally for a total period of 21 days .Blood samples
were collected at the end of the study and the results of the blood samples analysis showed
that group A, B, and C (control) had mean ALT levels of 10.4±3.32U/L,12.0±1.7U/L and
8.4±2.24U/L respectively while the mean AST levels were 20.2±4.66U/L, 23.8±4.65U/L and
24.0±5.59U/L respectively.There was no significant difference (P>0.05)in the levels of ALT
and AST among the 3 groups at 10mg/kg body weight dose level while there was significant
increase(p<0.05)in the ALT but no significant difference in the AST levels at 20mg/kg body
weight dose level between the treated and non-treated groups . The results of the study
showed that the ethanolic extract of Chromolaena odorata leaf at 10mg/kg body weight dose
level had no adverse effect on the liver of the experimental rats while at 20mg/kg body
weight it might be toxic to the liver. So the dose for human should be limited to less than
20mg/kg body weight dose level

Keywords: Chromolaena odorata, hepatotoxicity ,blood samples, ethanolic extract.

© 2013. Journal of Faculty of Biosciences, Nnamdi Azikiwe University,

P. M. B. 5025 Awka, Nigeria.

email: thebioscientist@unizik.edu.ng

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