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Malaria parasitemia and genotype of patients attending Tertiary Medical Center, in Katsina State was assessed. A total of 400 samples were collected from consented patients through venipuncture techniques. The blood samples were processed within 3 to 6 hours of collection. Using blood samples Infection status and genotype were screened using standard techniques. Their demographic characteristics were determined using questionnaires. Chi-square test was used to determine the degree of relationship between malarial parasite infection and genotype. Out of 400 consented patients examined, 193 patients (48.3%) were affected by malaria at varying degree of parasitemia. According to the gender, the prevalence of malaria was found to be (48.3%) among female respondents compared to their male counterparts with 48.1%(P>0.05). The results further showed that the subjects with normal genotypes are significantly more infected compared to those with S- gene. The occurrence of malarial infection among the participants with normal (AA) genotype is comparatively higher (53.8%) compared to the carrier (AS) participants with 41.7% and those with sickle cell disease (SS) having the least with 33.3%. Conclusively people with AS and SS genotype have more genetic advantage toward resistance to Malarial parasite infection. However, more scientific reasons require further elucidation.
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