The Effect of The Ethanolic Extract of The Leaf of Chromolaena odorata on The Liver of Wistar Albino Rats
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Abstract
The study investigated the hepatotoxic effect of the ethanolic extract of Chromolaena odorata leaf on groups of male wistar albino rats. The rats were divided into 3 groups of 5 rats each .Group A and B which were the treated groups received 10mg/kg and 20mg/kg body weight of the extract .Group C (control) was given 5% solution of tween 80 only. The administration of the extract was done orally for a total period of 21 days .Blood samples were collected at the end of the study and the results of the blood samples analysis showed that group A, B, and C (control) had mean ALT levels of 10.4±3.32U/L,12.0±1.7U/L and
8.4±2.24U/L respectively while the mean AST levels were 20.2±4.66U/L, 23.8±4.65U/L and 24.0±5.59U/L respectively.There was no significant difference (P>0.05)in the levels of ALT and AST among the 3 groups at 10mg/kg body weight dose level while there was significant increase (p<0.05) in the ALT but no significant difference in the AST levels at 20mg/kg body weight dose level between the treated and non-treated groups . The results of the study showed that the ethanolic extract of Chromolaena odorata leaf at 10mg/kg body weight dose level had no adverse effect on the liver of the experimental rats while at 20mg/kg body weight it might be toxic to the liver. So the dose for human should be limited to less than 20mg/kg body weight dose level.
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